Terminalia ferdinandiana (Kakadu Plum)-Mediated Bio-Synthesized ZnO Nanoparticles for Enhancement of Anti-Lung Cancer and Anti-Inflammatory Activities

Terminalia ferdinandiana (Kakadu plum) is an Australian native plant that has recently gained the attention of researchers due to its highly antioxidant compounds have substantial health benefits. To raise value, in this study, it used for first time synthesize ZnO nanoparticles anti-lung cancer and anti-inflammatory activities. The formation KKD-ZnO-NPs (ZnO particles obtained from Kakadu were confirmed using a UV-Visible spectrophotometer. Fourier transform infrared (FTIR) spectroscopy analysis functional groups are responsible stabilization capping KKD-ZnO-NPs. flower shape synthesized was by field emission-scanning electron microscopy (FE-SEM) emission-transmission (FE-TEM) analyses. crystallites pure had average size 21.89 nm as measured X-ray diffraction (XRD). dynamic light scattering (DLS) revealed range polydisperse 676.65 ± 47.23 with PDI 0.41 0.0634. Furthermore, potential cytotoxicity investigated vitro against human lung cell lines (A549) Raw 264.7 Murine macrophages cells normal ensure safety purposes MTT assay. Thus, showed prominent adenocarcinoma at 10 μg/mL increased reactive oxygen species (ROS) production well, which could promote toxicity cells. Moreover, upregulation p53 downregulation bcl2 gene expression apoptosis regulators via RT-PCR. In addition, possess similar capacity reduction proinflammatory-nitric oxide (NO) when compared L-NMMA inflammation’s inhibitor, indicating potential. Incorporation plum extract reducing stabilizing agents enabled green synthesis flower-shaped be initiative development effective therapy drug.